Reaction Details Report a problem with these data
Target
Muscarinic acetylcholine receptor M2
Ligand
BDBM50034873
Substrate
n/a
Meas. Tech.
ChEMBL_138162 (CHEMBL748226)
Ki
3.30±n/a nM
Citation
 Kiesewetter, DO; Silverton, JV; Eckelman, WC Syntheses and biological properties of chiral fluoroalkyl quinuclidinyl benzilates. J Med Chem 38:1711-9 (1995) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M2
Synonyms:
ACM2_RAT | Cholinergic, muscarinic M2 | Chrm-2 | Chrm2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51555.53
Organism:
RAT
Description:
P10980
Residue:
466
Sequence:
MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
  
Inhibitor
Name:
BDBM50034873
Synonyms:
(S)-(4-Fluoromethyl-phenyl)-hydroxy-phenyl-acetic acid 1-aza-bicyclo[2.2.2]oct-3-yl ester | CHEMBL47650
Type:
Small organic molecule
Emp. Form.:
C22H24FNO3
Mol. Mass.:
369.4293
SMILES:
O[C@@](C(=O)OC1CN2CCC1CC2)(c1ccccc1)c1ccc(CF)cc1 |wU:1.1,wD:1.0,TLB:4:5:9.8:11.12,(30.54,-13.96,;29.8,-15.3,;31.31,-15.85,;31.57,-17.36,;32.5,-14.88,;33.94,-15.41,;35.38,-15.55,;36.83,-16.72,;36.7,-18.54,;35.32,-18.32,;35.47,-16.49,;36.69,-15.88,;37.79,-16.24,;28.46,-14.53,;27.11,-15.3,;25.8,-14.53,;25.8,-12.99,;27.11,-12.2,;28.46,-12.97,;29,-16.62,;27.46,-16.59,;26.66,-17.91,;27.43,-19.25,;26.63,-20.59,;25.09,-20.57,;28.97,-19.28,;29.76,-17.94,)|
Structure:
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