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TargetMuscarinic acetylcholine receptor M3
LigandBDBM50036195
Substrate/Competitorn/a
Meas. Tech.ChEMBL_138314
Ki 160±n/a nM
Citation Nilsson, BMSundquist, SJohansson, GNordvall, GGlas, GNilvebrant, LHacksell, U 3-Heteroaryl-substituted quinuclidin-3-ol and quinuclidin-2-ene derivatives as muscarinic antagonists. Synthesis and structure-activity relationships. J Med Chem38:473-87 (1995) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Muscarinic acetylcholine receptor M3
Name:Muscarinic acetylcholine receptor M3
Synonyms:GPM3 | Muscarinic acetylcholine receptor
Type:n/a
Mol. Mass.:66272.13
Organism:Cavia porcellus
Description:n/a
Residue:587
Sequence:
MTLHSNSTTLPLFPNISTSWIHSPSEAGLPPGTVTHFGSYNISQAAGNFSSLNGTTSDPL
GGHTIWQVVFIAFLTGFLALVTIIGNILVIVSFKVNKQLKHVNNYFLLSLADLIIGVISM
NLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTT
KRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYM
PVTIMTILYWRIYKETEKRTKELAGLQASGTEAETENFVHPTGSSRSCSSYELQQQSLKH
SSRRKYSRCHFWFATKSWKPNAGQMDQDHSSSDSWNNYDAAASLENSASDEEDIGSETRA
IYSIVLKLPGHSTILNSTKLPSSDNLQVPEEDLEPMDMERNASKPQTQKSMDDGGSFQKS
FSNLPIQLESTMDTAKTSDANSSVSKTMATLPLSFKEATLAKRFALRTRSQITKRKRMSL
IKEKRAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVC
YALCNKTFRNTFKMLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQAL
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  Blast E-value cutoff:
BDBM50036195
NameBDBM50036195
Synonyms:3-Benzofuran-3-yl-1-aza-bicyclo[2.2.2]oct-2-ene | CHEMBL144385
TypeSmall organic molecule
Emp. Form.C15H15NO
Mol. Mass.225.2857
SMILESC1CN2CCC1C(=C2)c1coc2ccccc12 |c:7,(22.77,-5.83,;21.83,-6.3,;22.45,-7.56,;21.13,-6.9,;21.13,-5.36,;22.45,-4.58,;23.78,-5.36,;23.78,-6.9,;25.13,-4.59,;26.35,-5.52,;27.61,-4.64,;27.17,-3.16,;27.96,-1.85,;27.21,-.5,;25.67,-.48,;24.89,-1.78,;25.63,-3.13,)|
Structure
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n/a