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Target
Neutrophil elastase
Ligand
BDBM50036479
Substrate
n/a
Meas. Tech.
ChEMBL_64003 (CHEMBL673112)
Ki
15±n/a nM
Citation
 Hlasta, DJ; Subramanyam, C; Bell, MR; Carabateas, PM; Court, JJ; Desai, RC; Drozd, ML; Eickhoff, WM; Ferguson, EW; Gordon, RJ Orally bioavailable benzisothiazolone inhibitors of human leukocyte elastase. J Med Chem 38:739-44 (1995) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50036479
Synonyms:
1,1-Dioxo-2-(1-phenyl-1H-tetrazol-5-ylsulfanylmethyl)-1,2-dihydro-1lambda*6*-benzo[d]isothiazol-3-one | CHEMBL50803
Type:
Small organic molecule
Emp. Form.:
C15H11N5O3S2
Mol. Mass.:
373.41
SMILES:
O=C1N(CSc2nnnn2-c2ccccc2)S(=O)(=O)c2ccccc12
Structure:
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