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Target
Neutrophil elastase
Ligand
BDBM50036482
Substrate
n/a
Meas. Tech.
ChEMBL_64003 (CHEMBL673112)
Ki
0.2±n/a nM
Citation
 Hlasta, DJ; Subramanyam, C; Bell, MR; Carabateas, PM; Court, JJ; Desai, RC; Drozd, ML; Eickhoff, WM; Ferguson, EW; Gordon, RJ Orally bioavailable benzisothiazolone inhibitors of human leukocyte elastase. J Med Chem 38:739-44 (1995) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50036482
Synonyms:
2,6-Dichloro-3-(4-methyl-piperazine-1-sulfonyl)-benzoic acid 6-hydroxy-4-isopropyl-1,1,3-trioxo-1,3-dihydro-1lambda*6*-benzo[d]isothiazol-2-ylmethyl ester | CHEMBL162863
Type:
Small organic molecule
Emp. Form.:
C23H25Cl2N3O8S2
Mol. Mass.:
606.496
SMILES:
CC(C)c1cc(O)cc2c1C(=O)N(COC(=O)c1c(Cl)ccc(c1Cl)S(=O)(=O)N1CCN(C)CC1)S2(=O)=O
Structure:
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