Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50036716
Substrate
n/a
Meas. Tech.
ChEBML_201714
IC50
8±n/a nM
Citation
 Schuster, DI; Pan, YP; Singh, G; Stoupakis, G; Cai, B; Lem, G; Ehrlich, GK; Frietze, W; Murphy, RB N-(1-arylpropionyl)-4-aryltetrahydropyridines, a new class of high-affinity selective sigma receptor ligands. J Med Chem 36:3923-8 (1994) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50036716
Synonyms:
1-Phenyl-3-(4-phenyl-3,6-dihydro-2H-pyridin-1-yl)-propan-1-one | CHEMBL130357
Type:
Small organic molecule
Emp. Form.:
C20H21NO
Mol. Mass.:
291.3868
SMILES:
O=C(CCN1CCC(=CC1)c1ccccc1)c1ccccc1 |c:7|
Structure:
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