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TargetDopamine D1B
LigandBDBM50029257
Substrate/Competitorn/a
Meas. Tech.ChEMBL_61337
Ki>5000±n/a nM
Citation Reitz, ABBennett, DJBlum, PSCodd, EEMaryanoff, CAOrtegon, MERenzi, MJScott, MKShank, RPVaught, JL A new arylpiperazine antipsychotic with high D2/D3/5-HT1A/alpha 1A-adrenergic affinity and a low potential for extrapyramidal effects. J Med Chem37:1060-2 (1994) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dopamine D1B
Name:Dopamine receptor
Synonyms:D(1B) dopamine receptor | DOPAMINE D5 | Dopamine D5 receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:52827.88
Organism:RAT
Description:Dopamine D1B 0 RAT::P25115
Residue:475
Sequence:
MLPPGRNRTAQPARLGLQRQLAQVDAPAGSATPLGPAQVVTAGLLTLLIVWTLLGNVLVC
AAIVRSRHLRAKMTNIFIVSLAVSDLFVALLVMPWKAVAEVAGYWPFGTFCDIWVAFDIM
CSTASILNLCIISVDRYWAISRPFRYERKMTQRVALVMVGLAWTLSILISFIPVQLNWHR
DKAGSQGQEGLLSNGTPWEEGWELEGRTENCDSSLNRTYAISSSLISFYIPVAIMIVTYT
RIYRIAQVQIRRISSLERAAEHAQSCRSRGAYEPDPSLRASIKKETKVFKTLSMIMGVFV
CCWLPFFILNCMVPFCSSGDAEGPKTGFPCVSETTFDIFVWFGWANSSLNPIIYAFNADF
RKVFAQLLGCSHFCFRTPVQTVNISNELISYNQDTVFHKEIATAYVHMIPNAVSSGDREV
GEEEEEGPFDHMSQISPTTPDGDLAAESVWELDCEEEVSLGKISPLTPNCFDKTA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50029257
NameBDBM50029257
Synonyms:(3-((4-(2-isopropoxyphenyl)piperazin-1-yl)methyl)phenyl)(piperidin-1-yl)methanone | CHEMBL10085 | RWJ-377796 | mazapertine | {3-[4-(2-Isopropoxy-phenyl)-piperazin-1-ylmethyl]-phenyl}-piperidin-1-yl-methanone
TypeSmall organic molecule
Emp. Form.C26H35N3O2
Mol. Mass.421.575
SMILESCC(C)Oc1ccccc1N1CCN(Cc2cccc(c2)C(=O)N2CCCCC2)CC1
Structure
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n/a