Reaction Details Report a problem with these data
Target
Adenosine receptor A2a
Ligand
BDBM50493150
Substrate
n/a
Meas. Tech.
ChEMBL_980555 (CHEMBL2422901)
Ki
0.140000±n/a nM
Citation
 Mishra, CB; Sharma, D; Prakash, A; Kumari, N; Kumar, N; Luthra, PM Design and synthesis of (4E)-4-(4-substitutedbenzylideneamino)-3-substituted-2,3-dihydro-2-thioxothiazole-5-carbonitrile as novel A2A receptor antagonists. Bioorg Med Chem 21:6077-83 (2013) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM50493150
Synonyms:
CHEMBL2419140
Type:
Small organic molecule
Emp. Form.:
C17H10ClN3S2
Mol. Mass.:
355.864
SMILES:
Clc1ccc(\C=N\c2c(sc(=S)n2-c2ccccc2)C#N)cc1
Structure:
Search PDB for entries with ligand similarity: