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TargetSterol O-acyltransferase, Soat
LigandBDBM50038900
Substrate/Competitorn/a
Meas. Tech.ChEMBL_28505
IC50 9.3±n/a nM
Citation Tawada, HHarcourt, MKawamura, NKajino, MIshikawa, ESugiyama, YIkeda, HMeguro, K Novel acyl-CoA:cholesterol acyltransferase inhibitors. Synthesis and biological activity of 3-quinolylurea derivatives. J Med Chem37:2079-84 (1994) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Sterol O-acyltransferase, Soat
Name:Sterol O-acyltransferase, Soat
Synonyms:ACAT-1 | Cholesterol acyltransferase 1
Type:PROTEIN
Mol. Mass.:64165.56
Organism:Rattus norvegicus
Description:ChEMBL_28796
Residue:545
Sequence:
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLF
LKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISR
RSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVI
WTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLA
YTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPT
LIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLC
VFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVH
DWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMA
FNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWT
CRYVF
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  Blast E-value cutoff:
BDBM50038900
NameBDBM50038900
Synonyms:1-(7-Chloro-6-methyl-4-o-tolyl-quinolin-3-yl)-3-(2,4-difluoro-phenyl)-urea | CHEMBL63019
TypeSmall organic molecule
Emp. Form.C24H18ClF2N3O
Mol. Mass.437.869
SMILESCc1ccccc1-c1c(NC(=O)Nc2ccc(F)cc2F)cnc2cc(Cl)c(C)cc12 |(.68,-4.93,;2.01,-5.7,;2.01,-7.24,;3.34,-8.01,;4.67,-7.22,;4.7,-5.7,;3.34,-4.93,;3.34,-3.39,;4.67,-2.62,;6.02,-3.38,;7.35,-2.61,;7.33,-1.07,;8.69,-3.37,;8.69,-4.91,;7.36,-5.68,;7.37,-7.22,;8.71,-7.99,;8.73,-9.53,;10.04,-7.19,;10.03,-5.67,;11.36,-4.88,;4.67,-1.07,;3.34,-.31,;2.01,-1.08,;.68,-.31,;-.65,-1.08,;-1.98,-.33,;-.65,-2.64,;-1.98,-3.41,;.68,-3.39,;2.01,-2.62,)|
Structure
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