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Target
Sterol O-acyltransferase 1
Ligand
BDBM50038901
Substrate
n/a
Meas. Tech.
ChEMBL_28505 (CHEMBL645934)
IC50
21.2±n/a nM
Citation
 Tawada, H; Harcourt, M; Kawamura, N; Kajino, M; Ishikawa, E; Sugiyama, Y; Ikeda, H; Meguro, K Novel acyl-CoA:cholesterol acyltransferase inhibitors. Synthesis and biological activity of 3-quinolylurea derivatives. J Med Chem 37:2079-84 (1994) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat
Type:
PROTEIN
Mol. Mass.:
64165.56
Organism:
Rattus norvegicus
Description:
ChEMBL_28796
Residue:
545
Sequence:
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLFLKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISRRSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVIWTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLAYTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWTCRYVF
  
Inhibitor
Name:
BDBM50038901
Synonyms:
1-[6-Chloro-4-(2-chloro-phenyl)-quinolin-3-yl]-3-(2,4-difluoro-phenyl)-urea | CHEMBL62464
Type:
Small organic molecule
Emp. Form.:
C22H13Cl2F2N3O
Mol. Mass.:
444.261
SMILES:
Fc1ccc(NC(=O)Nc2cnc3ccc(Cl)cc3c2-c2ccccc2Cl)c(F)c1 |(9.52,-8.56,;9.5,-7.02,;8.17,-6.26,;8.15,-4.72,;9.48,-3.95,;9.48,-2.41,;8.14,-1.64,;8.13,-.1,;6.81,-2.43,;5.47,-1.66,;5.47,-.1,;4.13,.65,;2.81,-.12,;1.47,.65,;.14,-.12,;.14,-1.66,;-1.21,-2.43,;1.47,-2.43,;2.81,-1.66,;4.14,-2.43,;4.14,-3.97,;5.49,-4.74,;5.48,-6.26,;4.14,-7.05,;2.81,-6.28,;2.81,-4.74,;1.48,-3.97,;10.83,-4.7,;12.16,-3.92,;10.83,-6.24,)|
Structure:
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