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Target
Sterol O-acyltransferase 1
Ligand
BDBM50038912
Substrate
n/a
Meas. Tech.
ChEMBL_28505 (CHEMBL645934)
IC50
16.8±n/a nM
Citation
 Tawada, H; Harcourt, M; Kawamura, N; Kajino, M; Ishikawa, E; Sugiyama, Y; Ikeda, H; Meguro, K Novel acyl-CoA:cholesterol acyltransferase inhibitors. Synthesis and biological activity of 3-quinolylurea derivatives. J Med Chem 37:2079-84 (1994) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat
Type:
PROTEIN
Mol. Mass.:
64165.56
Organism:
Rattus norvegicus
Description:
ChEMBL_28796
Residue:
545
Sequence:
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLFLKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISRRSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVIWTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLAYTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWTCRYVF
  
Inhibitor
Name:
BDBM50038912
Synonyms:
1-[4-(2-Chloro-phenyl)-6-methyl-quinolin-3-yl]-3-(2,4-difluoro-phenyl)-urea | CHEMBL62894
Type:
Small organic molecule
Emp. Form.:
C23H16ClF2N3O
Mol. Mass.:
423.842
SMILES:
Cc1ccc2ncc(NC(=O)Nc3ccc(F)cc3F)c(-c3ccccc3Cl)c2c1 |(-13.32,-5.89,;-11.98,-5.12,;-11.98,-3.57,;-10.68,-2.8,;-9.33,-3.57,;-8,-2.78,;-6.67,-3.55,;-6.67,-5.09,;-5.32,-5.86,;-3.99,-5.09,;-4.01,-3.55,;-2.65,-5.86,;-2.65,-7.4,;-3.98,-8.17,;-3.97,-9.71,;-2.63,-10.46,;-2.61,-12,;-1.3,-9.68,;-1.31,-8.15,;.02,-7.36,;-8,-5.88,;-8,-7.42,;-9.33,-8.17,;-9.33,-9.71,;-8,-10.48,;-6.65,-9.71,;-6.64,-8.17,;-5.1,-8.17,;-9.33,-5.11,;-10.66,-5.86,)|
Structure:
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