Target
Sterol O-acyltransferase 1
Ligand
BDBM50038917
Substrate
n/a
Meas. Tech.
ChEMBL_28505 (CHEMBL645934)
IC50
121±n/a nM
Citation
 Tawada, HHarcourt, MKawamura, NKajino, MIshikawa, ESugiyama, YIkeda, HMeguro, K Novel acyl-CoA:cholesterol acyltransferase inhibitors. Synthesis and biological activity of 3-quinolylurea derivatives. J Med Chem 37:2079-84 (1994) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat
Type:
PROTEIN
Mol. Mass.:
64165.56
Organism:
Rattus norvegicus
Description:
ChEMBL_28796
Residue:
545
Sequence:
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLFLKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISRRSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVIWTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLAYTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWTCRYVF
  
Inhibitor
Name:
BDBM50038917
Synonyms:
1-[6-Chloro-4-(4-methoxy-phenyl)-quinolin-3-yl]-3-(2,4-difluoro-phenyl)-urea | CHEMBL278042
Type:
Small organic molecule
Emp. Form.:
C23H16ClF2N3O2
Mol. Mass.:
439.842
SMILES:
COc1ccc(cc1)-c1c(NC(=O)Nc2ccc(F)cc2F)cnc2ccc(Cl)cc12
Structure:
Search PDB for entries with ligand similarity: