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Target
Sterol O-acyltransferase 1
Ligand
BDBM50038919
Substrate
n/a
Meas. Tech.
ChEMBL_28505 (CHEMBL645934)
IC50
14±n/a nM
Citation
 Tawada, H; Harcourt, M; Kawamura, N; Kajino, M; Ishikawa, E; Sugiyama, Y; Ikeda, H; Meguro, K Novel acyl-CoA:cholesterol acyltransferase inhibitors. Synthesis and biological activity of 3-quinolylurea derivatives. J Med Chem 37:2079-84 (1994) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat
Type:
PROTEIN
Mol. Mass.:
64165.56
Organism:
Rattus norvegicus
Description:
ChEMBL_28796
Residue:
545
Sequence:
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLFLKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISRRSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVIWTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLAYTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWTCRYVF
  
Inhibitor
Name:
BDBM50038919
Synonyms:
1-[4-(2-Chloro-phenyl)-6-ethyl-quinolin-3-yl]-3-(2,4-difluoro-phenyl)-urea | CHEMBL63408
Type:
Small organic molecule
Emp. Form.:
C24H18ClF2N3O
Mol. Mass.:
437.869
SMILES:
CCc1ccc2ncc(NC(=O)Nc3ccc(F)cc3F)c(-c3ccccc3Cl)c2c1 |(2.57,-2.46,;3.92,-3.23,;5.25,-2.45,;5.25,-.91,;6.58,-.12,;7.92,-.89,;9.24,-.12,;10.58,-.89,;10.58,-2.43,;11.92,-3.2,;13.25,-2.43,;13.24,-.89,;14.59,-3.18,;14.59,-4.72,;13.26,-5.49,;13.28,-7.03,;14.61,-7.8,;14.63,-9.34,;15.94,-7.01,;15.94,-5.48,;17.27,-4.7,;9.25,-3.2,;9.25,-4.74,;7.92,-5.51,;7.92,-7.05,;9.25,-7.82,;10.59,-7.03,;10.6,-5.51,;12.09,-5.91,;7.92,-2.43,;6.59,-3.2,)|
Structure:
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