Reaction Details Report a problem with these data
Target
Retinoic acid receptor alpha
Ligand
BDBM50040012
Substrate
n/a
Meas. Tech.
ChEMBL_197386 (CHEMBL799705)
EC50
>10000±n/a nM
Citation
 Boehm, MF; Zhang, L; Badea, BA; White, SK; Mais, DE; Berger, E; Suto, CM; Goldman, ME; Heyman, RA Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids. J Med Chem 37:2930-41 (1994) [PubMed]  Article 
Target
Name:
Retinoic acid receptor alpha
Synonyms:
NR1B1 | Nuclear receptor subfamily 1 group B member 1 | RAR-alpha | RARA | RARA_HUMAN | Retinoic acid receptor alpha | Retinoic acid receptor alpha/Retinoid X receptor alpha | Retinoid X receptor gamma/retinoic acid receptor alpha | Retinoid receptor
Type:
PROTEIN
Mol. Mass.:
50778.87
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1466191
Residue:
462
Sequence:
MASNSSSCPTPGGGHLNGYPVPPYAFFFPPMLGGLSPPGALTTLQHQLPVSGYSTPSPATIETQSSSSEEIVPSPPSPPPLPRIYKPCFVCQDKSSGYHYGVSACEGCKGFFRRSIQKNMVYTCHRDKNCIINKVTRNRCQYCRLQKCFEVGMSKESVRNDRNKKKKEVPKPECSESYTLTPEVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELSTKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQDTMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAICLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKITDLRSISAKGAERVITLKMEIPGSMPPLIQEMLENSEGLDTLSGQPGGGGRDGGGLAPPPGSCSPSLSPSSNRSSPATHSP
  
Inhibitor
Name:
BDBM50040012
Synonyms:
4-[1-(3-Bromo-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-vinyl]-benzoic acid | CHEMBL101661
Type:
Small organic molecule
Emp. Form.:
C23H25BrO2
Mol. Mass.:
413.347
SMILES:
CC1(C)CCC(C)(C)c2cc(C(=C)c3ccc(cc3)C(O)=O)c(Br)cc12
Structure:
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