Reaction Details Report a problem with these data
Target
Phospholipase A2, membrane associated
Ligand
BDBM50040461
Substrate
n/a
Meas. Tech.
ChEMBL_156191 (CHEMBL761442)
IC50
21±n/a nM
Citation
 Beaton, HG; Bennion, C; Connolly, S; Cook, AR; Gensmantel, NP; Hallam, C; Hardy, K; Hitchin, B; Jackson, CG; Robinson, DH Discovery of new non-phospholipid inhibitors of the secretory phospholipases A2. J Med Chem 37:557-9 (1994) [PubMed]  Article 
Target
Name:
Phospholipase A2, membrane associated
Synonyms:
GIIC sPLA2 | Group IIA phospholipase A2 | NPS-PLA2 | Non-Pancreatic Secretory Phospholipase A2 | Non-pancreatic secretory phospholipase A2 (hnps-PLA2) | PA2GA_HUMAN | PLA2B | PLA2G2A | PLA2L | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 group IIA | RASF-A
Type:
Hydrolase
Mol. Mass.:
16101.20
Organism:
Homo sapiens (Human)
Description:
The human nps PLA2 was cloned, and expressed in E. coli. There was a refolding process in the purification.
Residue:
144
Sequence:
MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC
  
Inhibitor
Name:
BDBM50040461
Synonyms:
(S)-5-(4-Benzyl-phenylsulfanyl)-4-((S)-7-phenyl-heptanoylamino)-pentanoic acid | (S)-5-(4-Benzyl-phenylsulfanyl)-4-(7-phenyl-heptanoylamino)-pentanoic acid | CHEMBL434630
Type:
Small organic molecule
Emp. Form.:
C31H37NO3S
Mol. Mass.:
503.695
SMILES:
OC(=O)CC[C@@H](CSc1ccc(Cc2ccccc2)cc1)NC(=O)CCCCCCc1ccccc1
Structure:
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