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TargetDihydrofolate Reductase (DHFR)
LigandBDBM50041178
Substrate/Competitorn/a
Meas. Tech.ChEMBL_53004
IC50>35000±n/a nM
Citation Gangjee, ADevraj, RMcGuire, JJKisliuk, RLQueener, SFBarrows, LR Classical and nonclassical furo[2,3-d]pyrimidines as novel antifolates: synthesis and biological activities. J Med Chem37:1169-76 (1994) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate Reductase (DHFR)
Name:Dihydrofolate reductase; P. carinii vs rat
Synonyms:Dihydrofolate reductase | Tetrahydrofolate dehydrogenase
Type:Enzyme
Mol. Mass.:23891.29
Organism:Pneumocystis carinii
Description:n/a
Residue:206
Sequence:
MNQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRK
TWESIPLQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRI
FVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLESW
VGTKVPHGKINEDGFDYEFEMWTRDL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50041178
NameBDBM50041178
Synonyms:5-((3,4-dichlorophenylamino)methyl)furo[2,3-d]pyrimidine-2,4-diamine | 5-[(3,4-Dichloro-phenylamino)-methyl]-furo[2,3-d]pyrimidine-2,4-diamine | CHEMBL274278
TypeSmall organic molecule
Emp. Form.C13H11Cl2N5O
Mol. Mass.324.165
SMILESNc1nc(N)c2c(CNc3ccc(Cl)c(Cl)c3)coc2n1
Structure
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n/a