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TargetDihydrofolate Reductase (DHFR)
LigandBDBM50041176
Substrate/Competitorn/a
Meas. Tech.ChEMBL_53004
IC50 35±n/a nM
Citation Gangjee, ADevraj, RMcGuire, JJKisliuk, RLQueener, SFBarrows, LR Classical and nonclassical furo[2,3-d]pyrimidines as novel antifolates: synthesis and biological activities. J Med Chem37:1169-76 (1994) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate Reductase (DHFR)
Name:Dihydrofolate reductase; P. carinii vs rat
Synonyms:Dihydrofolate reductase | Tetrahydrofolate dehydrogenase
Type:Enzyme
Mol. Mass.:23891.29
Organism:Pneumocystis carinii
Description:n/a
Residue:206
Sequence:
MNQQKSLTLIVALTTSYGIGRSNSLPWKLKKEISYFKRVTSFVPTFDSFESMNVVLMGRK
TWESIPLQFRPLKGRINVVITRNESLDLGNGIHSAKSLDHALELLYRTYGSESSVQINRI
FVIGGAQLYKAAMDHPKLDRIMATIIYKDIHCDVFFPLKFRDKEWSSVWKKEKHSDLESW
VGTKVPHGKINEDGFDYEFEMWTRDL
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  Blast E-value cutoff:
BDBM50041176
NameBDBM50041176
Synonyms:2-{4-[(2,4-Diamino-furo[2,3-d]pyrimidin-5-ylmethyl)-methyl-amino]-benzoylamino}-pentanedioic acid | CHEMBL278515
TypeSmall organic molecule
Emp. Form.C20H22N6O6
Mol. Mass.442.4253
SMILESCN(Cc1coc2nc(N)nc(N)c12)c1ccc(cc1)C(=O)NC(CCC(O)=O)C(O)=O
Structure
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