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TargetDihydrofolate reductase
LigandBDBM50041175
Substrate/Competitorn/a
Meas. Tech.ChEMBL_54129
IC50>26000±n/a nM
Citation Gangjee, ADevraj, RMcGuire, JJKisliuk, RLQueener, SFBarrows, LR Classical and nonclassical furo[2,3-d]pyrimidines as novel antifolates: synthesis and biological activities. J Med Chem37:1169-76 (1994) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:Dihydrofolate reductase (DHFR) | Tetrahydrofolate dehydrogenase
Type:Enzyme
Mol. Mass.:21453.99
Organism:Homo sapiens (Human)
Description:Recombinant human DHFR.
Residue:187
Sequence:
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
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  Blast E-value cutoff:
BDBM50041175
NameBDBM50041175
Synonyms:5-[(3,4,5-Trimethoxy-phenylamino)-methyl]-furo[2,3-d]pyrimidine-2,4-diamine | CHEMBL16950
TypeSmall organic molecule
Emp. Form.C16H19N5O4
Mol. Mass.345.3532
SMILESCOc1cc(NCc2coc3nc(N)nc(N)c23)cc(OC)c1OC
Structure
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n/a