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Target
Cysteinyl leukotriene receptor 1
Ligand
BDBM50041337
Substrate
n/a
Meas. Tech.
ChEMBL_152998 (CHEMBL759482)
Ki
2.4±n/a nM
Citation
 Jacobs, RT; Bernstein, PR; Cronk, LA; Vacek, EP; Newcomb, LF; Aharony, D; Buckner, CK; Kusner, EJ Synthesis, structure-activity relationships, and pharmacological evaluation of a series of fluorinated 3-benzyl-5-indolecarboxamides: identification of 4-[[5-[((2R)-2-methyl-4,4,4-trifluorobutyl)carbamoyl]-1-methyl indol- 3-yl]methyl]-3-methoxy-N-[(2-methylphenyl)sulfonyl]benzamide, a potent, orall J Med Chem 37:1282-97 (1994) [PubMed]  Article 
Target
Name:
Cysteinyl leukotriene receptor 1
Synonyms:
CLTR1_CAVPO | CYSLTR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39007.58
Organism:
GUINEA PIG
Description:
Leukotriene D4 0 GUINEA PIG::Q2NNR5
Residue:
340
Sequence:
MDETGNPTIPPASNNTCYDSIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLVKTYHEKSAFQVYMINLAVADLLCVCTLPLRVAYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCVAIVFPVQNISLVTQKKARLVCIAIWMFVILTSSPFLMANTYKDEKNNTKCFEPPQDNQAKNYVLILHYVSLFIGFIIPFITIIVCYTMIIFTLLKSSMKKNLSSRKRAIGMIIVVTAAFLVSFMPYHIQRTIHLHFLHNKTKPCDSILRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRRRLSTIRKYSLSSMTYIPKKKTSLPQKGKDICKE
  
Inhibitor
Name:
BDBM50041337
Synonyms:
3-[4-(2-Bromo-benzenesulfonylaminocarbonyl)-2-methoxy-benzyl]-1-methyl-1H-indole-5-carboxylic acid (2-ethyl-4,4,4-trifluoro-butyl)-amide | CHEMBL26002
Type:
Small organic molecule
Emp. Form.:
C31H31BrF3N3O5S
Mol. Mass.:
694.559
SMILES:
CCC(CNC(=O)c1ccc2n(C)cc(Cc3ccc(cc3OC)C(=O)NS(=O)(=O)c3ccccc3Br)c2c1)CC(F)(F)F
Structure:
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