Reaction Details Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50041721
Substrate
n/a
Meas. Tech.
ChEMBL_44886 (CHEMBL656581)
IC50
16±n/a nM
Citation
 Holmes, JM; Lee, GC; Wijono, M; Weinkam, R; Wheeler, LA; Garst, ME Synthesis and carbonic anhydrase inhibitory activity of 4-substituted 2-thiophenesulfonamides. J Med Chem 37:1646-51 (1994) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50041721
Synonyms:
4-Acetyl-thiophene-2-sulfonic acid amide | CHEMBL287738
Type:
Small organic molecule
Emp. Form.:
C6H7NO3S2
Mol. Mass.:
205.255
SMILES:
CC(=O)c1csc(c1)S(N)(=O)=O
Structure:
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