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Target
Type-1 angiotensin II receptor
Ligand
BDBM50042546
Substrate
n/a
Meas. Tech.
ChEBML_36933
IC50
20±n/a nM
Citation
 Ashton, WT; Hutchins, SM; Greenlee, WJ; Doss, GA; Chang, RS; Lotti, VJ; Faust, KA; Chen, TB; Zingaro, GJ; Kivlighn, SD Nonpeptide angiotensin II antagonists derived from 1H-pyrazole-5-carboxylates and 4-aryl-1H-imidazole-5-carboxylates. J Med Chem 36:3595-605 (1994) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1_RABIT | ANGIOTENSIN AT1 | Angiotensin II receptor | Angiotensin II type 1a (AT-1a) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41009.15
Organism:
RABBIT
Description:
ANGIOTENSIN AT1 AGTR1 RABBIT::P34976
Residue:
359
Sequence:
MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
  
Inhibitor
Name:
BDBM50042546
Synonyms:
2-(2,6-Dichloro-phenyl)-5-propyl-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2H-pyrazole-3-carboxylic acid ethyl ester | CHEMBL331078
Type:
Small organic molecule
Emp. Form.:
C29H26Cl2N6O2
Mol. Mass.:
561.462
SMILES:
CCCc1nn(c(C(=O)OCC)c1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)-c1c(Cl)cccc1Cl |(-3.03,-3.44,;-1.58,-2.96,;-.44,-4,;1.03,-3.52,;1.5,-2.05,;3.04,-2.05,;3.53,-3.51,;4.99,-3.99,;5.28,-4.84,;6.14,-2.96,;7.61,-3.44,;8.75,-2.41,;2.27,-4.42,;2.27,-5.96,;3.6,-6.73,;4.95,-5.96,;6.28,-6.73,;6.28,-8.27,;4.95,-9.04,;3.62,-8.27,;7.61,-9.04,;7.61,-10.58,;8.94,-11.35,;10.27,-10.58,;10.27,-9.04,;8.94,-8.27,;8.92,-6.73,;10.16,-5.82,;9.69,-4.36,;8.15,-4.37,;7.68,-5.83,;3.95,-.8,;3.32,.6,;1.8,.75,;4.21,1.84,;5.76,1.68,;6.39,.27,;5.49,-.96,;6.82,-1.73,)|
Structure:
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