Reaction Details Report a problem with these data
Target
Type-1 angiotensin II receptor B
Ligand
BDBM50043277
Substrate
n/a
Meas. Tech.
ChEMBL_34819 (CHEMBL648963)
IC50
4±n/a nM
Citation
 Ries, UJ; Mihm, G; Narr, B; Hasselbach, KM; Wittneben, H; Entzeroth, M; van Meel, JC; Wienen, W; Hauel, NH 6-Substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure-activity relationships. J Med Chem 36:4040-51 (1994) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor B
Synonyms:
AGTRB_RAT | AT3 | Agtr1 | Agtr1b | Angiotensin II AT1B | Angiotensin II receptor (AT-1) type-1 | Angiotensin II type 1b (AT-1b) receptor | At1b | Type-1B angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40929.44
Organism:
RAT
Description:
Angiotensin II AT1B 0 RAT::P29089
Residue:
359
Sequence:
MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE
  
Inhibitor
Name:
BDBM50043277
Synonyms:
1-{2-Butyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3H-benzoimidazol-5-yl}-piperidin-2-one | CHEMBL128922
Type:
Small organic molecule
Emp. Form.:
C30H31N7O
Mol. Mass.:
505.6134
SMILES:
CCCCc1nc2ccc(cc2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)N1CCCCC1=O
Structure:
Search PDB for entries with ligand similarity: