Reaction Details Report a problem with these data
Target
Interstitial collagenase
Ligand
BDBM50043598
Substrate
n/a
Meas. Tech.
ChEMBL_49504 (CHEMBL662799)
IC50
>100000±n/a nM
Citation
Chapman, KT; Kopka, IE; Durette, PL; Esser, CK; Lanza, TJ; Izquierdo-Martin, M; Niedzwiecki, L; Chang, B; Harrison, RK; Kuo, DW Inhibition of matrix metalloproteinases by N-carboxyalkyl peptides. J Med Chem 36:4293-301 (1994) [PubMed] Article
More Info.:
Target
Name:
Interstitial collagenase
Synonyms:
CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1)
Type:
Enzyme
Mol. Mass.:
54010.26
Organism:
Homo sapiens (Human)
Description:
P03956
Residue:
469
Sequence:
MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPVVEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIENYTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGNLAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSYTFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
Inhibitor
Name:
BDBM50043598
Synonyms:
1N-[1-[1-carbamoyl-2-phenyl-(1S)-ethylcarbamoyl]-3-methyl-(1S)-butyl]-2-amino-4-methyl-(2R)-pentanamide | CHEMBL133199
Type:
Small organic molecule
Emp. Form.:
C21H34N4O3
Mol. Mass.:
390.5197
SMILES:
CC(C)C[C@@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(N)=O