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Target
Type-1 angiotensin II receptor B
Ligand
BDBM50044352
Substrate
n/a
Meas. Tech.
ChEBML_34826
IC50
43±n/a nM
Citation
 Huang, HC; Reitz, DB; Chamberlain, TS; Olins, GM; Corpus, VM; McMahon, EG; Palomo, MA; Koepke, JP; Smits, GJ; McGraw, DE Synthesis and structure-activity relationships of nonpeptide, potent triazolone-based angiotensin II receptor antagonists. J Med Chem 36:2172-81 (1993) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor B
Synonyms:
AGTRB_RAT | AT3 | Agtr1 | Agtr1b | Angiotensin II AT1B | Angiotensin II receptor (AT-1) type-1 | Angiotensin II type 1b (AT-1b) receptor | At1b | Type-1B angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
40929.44
Organism:
RAT
Description:
Angiotensin II AT1B 0 RAT::P29089
Residue:
359
Sequence:
MTLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNHLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLMAGLASLPAVIYRNVYFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFVFPFLIILTSYTLIWKALKKAYKIQKNTPRNDDIFRIIMAIVLFFFFSWVPHQIFTFLDVLIQLGIIRDCEIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPTAKSHAGLSTKMSTLSYRPSDNMSSSAKKSASFFEVE
  
Inhibitor
Name:
BDBM50044352
Synonyms:
5-Butyl-2-(1,1-dimethyl-2-oxo-2-phenyl-ethyl)-4-[2'-(2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2,4-dihydro-[1,2,4]triazol-3-one | CHEMBL69296
Type:
Small organic molecule
Emp. Form.:
C30H31N7O2
Mol. Mass.:
521.6128
SMILES:
CCCCc1nn(c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1)C(C)(C)C(=O)c1ccccc1
Structure:
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