Reaction Details Report a problem with these data
Target
Glycylpeptide N-tetradecanoyltransferase
Ligand
BDBM50496925
Substrate
n/a
Meas. Tech.
ChEMBL_1336013 (CHEMBL3238987)
Ki
113±n/a nM
Citation
 Rackham, MD; Brannigan, JA; Rangachari, K; Meister, S; Wilkinson, AJ; Holder, AA; Leatherbarrow, RJ; Tate, EW Design and synthesis of high affinity inhibitors of Plasmodium falciparum and Plasmodium vivax N-myristoyltransferases directed by ligand efficiency dependent lipophilicity (LELP). J Med Chem 57:2773-88 (2014) [PubMed]  Article 
Target
Name:
Glycylpeptide N-tetradecanoyltransferase
Synonyms:
Myristoyl-CoA:protein N-myristoyltransferase | NMT | NMT_PLAF7 | Peptide N-myristoyltransferase
Type:
PROTEIN
Mol. Mass.:
47977.09
Organism:
Plasmodium falciparum (isolate 3D7)
Description:
ChEMBL_862035
Residue:
410
Sequence:
MNDDKKDFVGRDLYQLIRNAKDKIKIDYKFWYTQPVPKINDEFDENVNEPFISDNKVEDVRKEEYKLPSGYAWCVCDITKENDRSDIYNLLTDNYVEDDDNVFRFNYSSEFLLWALSSPNYVKNWHIGVKYESTNKLVGFISAIPIDMCVNKNIIKMAEVNFLCVHKSLRSKRLAPVLIKEITRRINLESIWQAIYTAGVYLPKPISTARYFHRSINVKKLIEIGFSCLNTRLTMSRAIKLYRIDDTLNIKNLRLMKKKDIDGLQKLLNEHLKQYNLHAIFSKEDVAHWFTPIDQVIYTYVNEENGEIKDLISFYSLPSKVLGNNKYNILNAAFSFYNITTTTTFKNLIQDAICLAKRNNFDVFNALEVMDNYSVFQDLKFGEGDGSLKYYLYNWKCASCHPSKIGIVLL
  
Inhibitor
Name:
BDBM50496925
Synonyms:
CHEMBL3237437
Type:
Small organic molecule
Emp. Form.:
C21H22N4O3S
Mol. Mass.:
410.489
SMILES:
Cc1noc(C)c1Cc1nnc(o1)-c1sc2ccccc2c1OC1CCNCC1
Structure:
Search PDB for entries with ligand similarity: