Reaction Details Report a problem with these data
Target
S-adenosylmethionine decarboxylase proenzyme
Ligand
BDBM50046199
Substrate
n/a
Meas. Tech.
ChEBML_197689
IC50
>50000±n/a nM
Citation
 Stanek, J; Caravatti, G; Capraro, HG; Furet, P; Mett, H; Schneider, P; Regenass, U S-adenosylmethionine decarboxylase inhibitors: new aryl and heteroaryl analogues of methylglyoxal bis(guanylhydrazone). J Med Chem 36:46-54 (1993) [PubMed]  Article 
Target
Name:
S-adenosylmethionine decarboxylase proenzyme
Synonyms:
Amd1 | DCAM_RAT | S-adenosylmethionine decarboxylase 1
Type:
PROTEIN
Mol. Mass.:
38134.93
Organism:
Rattus norvegicus
Description:
ChEMBL_197052
Residue:
333
Sequence:
MEAAHFFEGTEKLLEVWFSRQQSDASQGSGDLRTIPRSEWDVLLKDVQCSIISVTKTDKQEAYVLSESSMFVSKRRFILKTCGTTLLLKALVPLLKLARDYSGFDSIQSFFYSRKNFMKPSHQGYPHRNFQEEIEFLNAIFPNGAAYCMGRMNSDCWYLYTLDLPESRVINQPDQTLEILMSELDPAVMDQFYMKDGVTAKDVTRESGIRDLIPGSVIDATLFNPCGYSMNGMKSDGTYWTIHITPEPEFSYVSFETNLSQTSYDDLIRKVVEVFKPGKFVTTLFVNQSSKCRTVLSSPQKIDGFKRLDCQSAMFNDYNFVFTSFAKKQQQQS
  
Inhibitor
Name:
BDBM50046199
Synonyms:
(2E)-2-{3-[(E)-amino(butylimino)methyl]benzylidene}hydrazinecarboximidamide | CHEMBL358674
Type:
Small organic molecule
Emp. Form.:
C13H20N6
Mol. Mass.:
260.3381
SMILES:
CCCCN=C(N)c1cccc(C=NNC(N)=N)c1 |w:12.11,4.3|
Structure:
Search PDB for entries with ligand similarity: