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Target
Leukotriene A-4 hydrolase
Ligand
BDBM50046339
Substrate
n/a
Meas. Tech.
ChEMBL_96936 (CHEMBL706177)
IC50
>1000000±n/a nM
Citation
 Yuan, W; Munoz, B; Wong, CH; Haeggström, JZ; Wetterholm, A; Samuelsson, B Development of selective tight-binding inhibitors of leukotriene A4 hydrolase. J Med Chem 36:211-20 (1993) [PubMed]  Article 
Target
Name:
Leukotriene A-4 hydrolase
Synonyms:
LKHA4_HUMAN | LTA-4 hydrolase | LTA4 | LTA4H | Leukotriene A(4) hydrolase | Leukotriene A-4 hydrolase (LTA4H) | Leukotriene A4 hydrolase
Type:
Hydrolase; metalloprotease
Mol. Mass.:
69280.41
Organism:
Homo sapiens (Human)
Description:
Human recombinant LTA4H.
Residue:
611
Sequence:
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD
  
Inhibitor
Name:
BDBM50046339
Synonyms:
(2S,3S)-3-Amino-2-hydroxy-4-phenyl-butyric acid | (2S,3S)-3-amino-2-hydroxy-4-phenylbutanoic acid | 3-Amino-2-hydroxy-4-phenyl-butyric acid | CHEMBL302932
Type:
Small organic molecule
Emp. Form.:
C10H13NO3
Mol. Mass.:
195.2151
SMILES:
N[C@@H](Cc1ccccc1)[C@H](O)C(O)=O
Structure:
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