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Target
Gag-Pol polyprotein [489-587]
Ligand
BDBM50046417
Substrate
n/a
Meas. Tech.
ChEMBL_159311 (CHEMBL769364)
IC50
7.1±n/a nM
Citation
Kempf, DJ; Codacovi, L; Wang, XC; Kohlbrenner, WE; Wideburg, NE; Saldivar, A; Vasavanonda, S; Marsh, KC; Bryant, P; Sham, HL Symmetry-based inhibitors of HIV protease. Structure-activity studies of acylated 2,4-diamino-1,5-diphenyl-3-hydroxypentane and 2,5-diamino-1,6-diphenylhexane-3,4-diol. J Med Chem 36:320-30 (1993) [PubMed] Article
More Info.:
Target
Name:
Gag-Pol polyprotein [489-587]
Synonyms:
Human immunodeficiency virus type 1 protease | POL_HV1H2 | Pol polyprotein | gag-pol
Type:
Enzyme Subunit
Mol. Mass.:
10781.16
Organism:
Human immunodeficiency virus type 1
Description:
P04585[489-587]
Residue:
99
Sequence:
PQVTLWQRPLVTIKIGGQLKEALLDTGADDTVLEEMSLPGRWKPKMIGGIGGFIKVRQYDQILIEICGHKAIGTVLVGPTPVNIIGRNLLTQIGCTLNF
Inhibitor
Name:
BDBM50046417
Synonyms:
3N-[1-[1-benzyl-2-hydroxy-3-[2-methyl-1-(1,2,3,4-tetrahydro-3-isoquinolinylcarboxamido)-(1S)-propylcarboxamido]-4-phenyl-(1S,3S)-butylcarbamoyl]-2-methyl-(1R)-propyl]-1,2,3,4-tetrahydro-3-isoquinolinecarboxamide | CHEMBL419580
Type:
Small organic molecule
Emp. Form.:
C47H58N6O5
Mol. Mass.:
787.0006
SMILES:
CC(C)[C@H](NC(=O)C1Cc2ccccc2CN1)C(=O)N[C@@H](Cc1ccccc1)C(O)[C@H](Cc1ccccc1)NC(=O)[C@H](NC(=O)C1Cc2ccccc2CN1)C(C)C