Target
Neuropeptide Y receptor type 2
Ligand
BDBM50046551
Substrate
n/a
Meas. Tech.
ChEMBL_144149 (CHEMBL750764)
Ki
0.3±n/a nM
Citation
 Kirby, DAKoerber, SCCraig, AGFeinstein, RDDelmas, LBrown, MRRivier, JE Defining structural requirements for neuropeptide Y receptors using truncated and conformationally restricted analogues. J Med Chem 36:385-93 (1993) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 2
Synonyms:
NPY-Y2 | NPY-Y2 receptor | NPY2-R | NPY2R | NPY2R_HUMAN | Neuropeptide Y receptor type 2 | Y2 receptor | neuropeptide Y receptor Y2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42734.65
Organism:
Homo sapiens (Human)
Description:
NPY-Y2 NPY2R HUMAN::P49146
Residue:
381
Sequence:
MGPIGAEADENQTVEEMKVEQYGPQTTPRGELVPDPEPELIDSTKLIEVQVVLILAYCSIILLGVIGNSLVIHVVIKFKSMRTVTNFFIANLAVADLLVNTLCLPFTLTYTLMGEWKMGPVLCHLVPYAQGLAVQVSTITLTVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVACTEKWPGEEKSIYGTVYSLSSLLILYVLPLGIISFSYTRIWSKLKNHVSPGAANDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDSQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLSAFRCEQRLDAIHSEVSVTFKAKKNLEVRKNSGPNDSFTEATNV
  
Inhibitor
Name:
BDBM50046551
Synonyms:
CHEMBL2370625 | Tyr-c(Glu-Ser-Lys-Pro-Gly-Arg-His-(DDpr))-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr
Type:
Small organic molecule
Emp. Form.:
C98H157N33O26
Mol. Mass.:
2213.5007
SMILES:
[H][C@@]12CCCN1C(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(=O)N[C@@H](CNC(=O)[C@@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](C)NC2=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O)NC(=O)[C@@H](N)Cc1ccc(O)cc1 |wU:95.97,63.65,23.148,79.81,133.135,34.35,113.115,96.100,55.57,88.91,1.0,wD:29.62,87.89,71.73,102.104,122.124,148.152,17.18,8.9,44.46,64.67,(-6.45,-17.84,;-5.3,-16.37,;-6.84,-16.6,;-7.58,-15.24,;-6.5,-14.15,;-5.1,-14.84,;-4.54,-13.41,;-5.91,-12.67,;-3.66,-12.16,;-4.82,-11.12,;-6.3,-11.6,;-7.46,-10.55,;-8.92,-11.03,;-10.11,-10,;-2.52,-11.15,;-1.16,-10.43,;-1.73,-8.99,;.35,-10.04,;.11,-8.5,;-1.34,-7.93,;1.9,-10,;3.42,-10.32,;3.89,-8.86,;4.83,-11,;6.05,-11.94,;7.03,-13.16,;7.7,-14.58,;9.16,-14.1,;8.02,-16.08,;7.99,-17.62,;7.6,-19.1,;6.88,-20.46,;5.85,-21.59,;6.89,-22.77,;4.58,-22.47,;5.32,-23.84,;6.89,-23.89,;7.82,-22.67,;9.29,-23.21,;9.26,-24.76,;7.77,-25.17,;3.15,-23.02,;1.62,-23.24,;1.68,-24.78,;.07,-23.1,;-.23,-24.6,;.94,-25.64,;.63,-27.14,;1.8,-28.17,;1.51,-29.69,;.04,-30.15,;2.67,-30.72,;-1.41,-22.6,;-2.75,-21.79,;-3.68,-22.99,;-3.85,-20.68,;-5.05,-21.63,;-4.68,-19.36,;-5.16,-17.9,;-6.68,-18.19,;9.53,-17.85,;10.2,-16.52,;10.71,-18.99,;12.08,-18.47,;12.34,-16.93,;13.73,-16.4,;11.23,-15.92,;11.49,-14.4,;13.19,-19.46,;12.94,-20.98,;14.58,-18.93,;15.69,-19.93,;15.43,-21.46,;16.54,-22.45,;17.91,-21.91,;16.28,-23.99,;17.06,-19.39,;17.33,-17.85,;18.18,-20.38,;19.56,-19.86,;19.81,-18.33,;21.18,-17.81,;21.46,-16.25,;22.28,-18.78,;20.66,-20.84,;20.4,-22.39,;22.05,-20.31,;23.16,-21.32,;22.88,-22.84,;24.01,-23.85,;21.52,-23.39,;21.25,-24.9,;24.53,-20.78,;24.8,-19.24,;25.64,-21.77,;27.03,-21.23,;27.28,-19.7,;26.18,-18.7,;28.65,-19.19,;28.14,-22.23,;27.87,-23.76,;29.5,-21.71,;30.63,-22.7,;30.35,-24.24,;31.46,-25.23,;31.21,-26.77,;32.31,-27.77,;32.06,-29.29,;33.17,-30.3,;30.68,-29.83,;32,-22.17,;32.26,-20.64,;33.11,-23.16,;34.49,-22.63,;34.76,-21.09,;36.12,-20.57,;36.4,-19.04,;35.29,-18.02,;37.77,-18.51,;35.61,-23.62,;35.34,-25.15,;36.97,-23.1,;38.08,-24.1,;37.83,-25.63,;38.92,-26.65,;38.68,-28.16,;39.79,-29.16,;39.53,-30.68,;40.64,-31.69,;38.16,-31.22,;39.46,-23.56,;39.73,-22.03,;40.58,-24.56,;41.96,-24.02,;42.23,-22.48,;43.59,-21.96,;44.72,-22.96,;46.09,-22.43,;46.35,-20.89,;47.74,-20.35,;45.24,-19.9,;43.85,-20.44,;43.08,-25.01,;44.45,-24.49,;42.8,-26.55,;5.64,-9.67,;7.19,-9.75,;7.94,-11.09,;7.99,-8.44,;9.55,-8.5,;7.24,-7.07,;7.31,-5.55,;8.11,-4.24,;7.37,-2.88,;5.81,-2.82,;5.27,-1.42,;4.98,-4.13,;5.75,-5.49,)|
Structure:
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