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Target
Thromboxane A2 receptor
Ligand
BDBM50047067
Substrate
n/a
Meas. Tech.
ChEMBL_207650 (CHEMBL811632)
Ki
15±n/a nM
Citation
 Nicolaï, E; Goyard, J; Benchetrit, T; Teulon, JM; Caussade, F; Virone, A; Delchambre, C; Cloarec, A Synthesis and structure-activity relationships of novel benzimidazole and imidazo[4,5-b]pyridine acid derivatives as thromboxane A2 receptor antagonists. J Med Chem 36:1175-87 (1993) [PubMed]  Article 
Target
Name:
Thromboxane A2 receptor
Synonyms:
Prostanoid TP receptor | TA2R_HUMAN | TBXA2R | TXA2-R | Thromboxane | Thromboxane A2 receptor | Thromboxane Beta
Type:
Enyzme
Mol. Mass.:
37445.28
Organism:
Homo sapiens (Human)
Description:
P21731
Residue:
343
Sequence:
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
  
Inhibitor
Name:
BDBM50047067
Synonyms:
4-[1-(4-Bromo-2-fluoro-benzyl)-5-fluoro-1H-benzoimidazol-2-yl]-3,3-dimethyl-butyric acid | CHEMBL277516
Type:
Small organic molecule
Emp. Form.:
C20H19BrF2N2O2
Mol. Mass.:
437.278
SMILES:
CC(C)(CC(O)=O)Cc1nc2cc(F)ccc2n1Cc1ccc(Br)cc1F
Structure:
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