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Target
Type-1 angiotensin II receptor
Ligand
BDBM50047794
Substrate
n/a
Meas. Tech.
ChEMBL_36941 (CHEMBL648844)
IC50
770±n/a nM
Citation
 Ashton, WT; Cantone, CL; Chang, LL; Hutchins, SM; Strelitz, RA; MacCoss, M; Chang, RS; Lotti, VJ; Faust, KA; Chen, TB Nonpeptide angiotensin II antagonists derived from 4H-1,2,4-triazoles and 3H-imidazo[1,2-b][1,2,4]triazoles. J Med Chem 36:591-609 (1993) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1_RABIT | ANGIOTENSIN AT1 | Angiotensin II receptor | Angiotensin II type 1a (AT-1a) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41009.15
Organism:
RABBIT
Description:
ANGIOTENSIN AT1 AGTR1 RABBIT::P34976
Residue:
359
Sequence:
MMLNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLAVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWVPHQIFTFLDVLIQLGVIHDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKKYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSSKKPVPCFEVE
  
Inhibitor
Name:
BDBM50047794
Synonyms:
CHEMBL158196 | N-[4-(3-Butyl-5-carboxymethylsulfanyl-[1,2,4]triazol-4-ylmethyl)-phenyl]-phthalamic acid
Type:
Small organic molecule
Emp. Form.:
C23H24N4O5S
Mol. Mass.:
468.525
SMILES:
CCCCc1nnc(SCC(O)=O)n1Cc1ccc(NC(=O)c2ccccc2C(O)=O)cc1
Structure:
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