Reaction Details Report a problem with these data
Target
Type-2 angiotensin II receptor
Ligand
BDBM50048119
Substrate
n/a
Meas. Tech.
ChEBML_35279
IC50
0.650000±n/a nM
Citation
 Plucinska, K; Kataoka, T; Yodo, M; Cody, WL; He, JX; Humblet, C; Lu, GH; Lunney, E; Major, TC; Panek, RL Multiple binding modes for the receptor-bound conformations of cyclic AII agonists. J Med Chem 36:1902-13 (1993) [PubMed]  Article 
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41201.61
Organism:
Homo sapiens (Human)
Description:
Angiotensin II, central 0 0::P50052
Residue:
363
Sequence:
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
  
Inhibitor
Name:
BDBM50048119
Synonyms:
CHEMBL385283 | c[Sar1-Arg2-Hcy3-Tyr4-MPt5-His6-Pro7-Phe8]
Type:
Small organic molecule
Emp. Form.:
C47H63N13O10S2
Mol. Mass.:
1034.214
SMILES:
CNCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CCSS[C@@H]2C[C@H](N(C2)C(=O)[C@H](Cc2ccc(O)cc2)NC1=O)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Structure:
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