Target
Dihydrofolate reductase
Ligand
BDBM50049592
Substrate
n/a
Meas. Tech.
ChEMBL_52843 (CHEMBL665047)
IC50
1600±n/a nM
Citation
 Gangjee, AZhu, YQueener, SFFrancom, PBroom, AD Nonclassical 2,4-diamino-8-deazafolate analogues as inhibitors of dihydrofolate reductases from rat liver, Pneumocystis carinii, and Toxoplasma gondii. J Med Chem 39:1836-45 (1996) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DFR1 | DYR_YEAST
Type:
PROTEIN
Mol. Mass.:
24263.24
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_52843
Residue:
211
Sequence:
MAGGKIPIVGIVACLQPEMGIGFRGGLPWRLPSEMKYFRQVTSLTKDPNKKNALIMGRKTWESIPPKFRPLPNRMNVIISRSFKDDFVHDKERSIVQSNSLANAIMNLESNFKEHLERIYVIGGGEVYSQIFSITDHWLITKINPLDKNATPAMDTFLDAKKLEEVFSEQDPAQLKEFLPPKVELPETDCDQRYSLEEKGYCFEFTLYNRK
  
Inhibitor
Name:
BDBM50049592
Synonyms:
6-[(2,5-Dichloro-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine | CHEMBL292212
Type:
Small organic molecule
Emp. Form.:
C14H12Cl2N6
Mol. Mass.:
335.191
SMILES:
Nc1nc(N)c2nc(CNc3cc(Cl)ccc3Cl)ccc2n1
Structure:
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