Target
Dihydrofolate reductase
Ligand
BDBM50049615
Substrate
n/a
Meas. Tech.
ChEMBL_55116 (CHEMBL884367)
IC50
570.0±n/a nM
Citation
 Gangjee, AZhu, YQueener, SFFrancom, PBroom, AD Nonclassical 2,4-diamino-8-deazafolate analogues as inhibitors of dihydrofolate reductases from rat liver, Pneumocystis carinii, and Toxoplasma gondii. J Med Chem 39:1836-45 (1996) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_RAT | Dhfr | Dihydrofolate reductase (DHFR) | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase
Type:
Enzyme
Mol. Mass.:
21638.84
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
187
Sequence:
MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFSIPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSSVYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKFEVYEKKD
  
Inhibitor
Name:
BDBM50049615
Synonyms:
6-[(2,4,6-Trichloro-phenylamino)-methyl]-pyrido[3,2-d]pyrimidine-2,4-diamine | CHEMBL51706
Type:
Small organic molecule
Emp. Form.:
C14H11Cl3N6
Mol. Mass.:
369.636
SMILES:
Nc1nc(N)c2nc(CNc3c(Cl)cc(Cl)cc3Cl)ccc2n1
Structure:
Search PDB for entries with ligand similarity: