Reaction Details Report a problem with these data
Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50050368
Substrate
n/a
Meas. Tech.
ChEMBL_28665 (CHEMBL649063)
IC50
290±n/a nM
Citation
 Kataoka, K; Shiota, T; Takeyasu, T; Minoshima, T; Watanabe, K; Tanaka, H; Mochizuki, T; Taneda, K; Ota, M; Tanabe, H; Yamaguchi, H Potent inhibitors of acyl-CoA:cholesterol acyltransferase. 2. Structure-activity relationships of novel N-(2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)amides. J Med Chem 39:1262-70 (1996) [PubMed]  Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50050368
Synonyms:
1-Decyl-cyclopentanecarboxylic acid (5-chloro-2,2,4,6-tetramethyl-2,3-dihydro-benzofuran-7-yl)-amide | CHEMBL23111
Type:
Small organic molecule
Emp. Form.:
C28H44ClNO2
Mol. Mass.:
462.107
SMILES:
CCCCCCCCCCC1(CCCC1)C(=O)Nc1c2OC(C)(C)Cc2c(C)c(Cl)c1C
Structure:
Search PDB for entries with ligand similarity: