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Target
Sterol O-acyltransferase 1
Ligand
BDBM50050362
Substrate
n/a
Meas. Tech.
ChEMBL_28799 (CHEMBL641709)
IC50
16±n/a nM
Citation
 Kataoka, K; Shiota, T; Takeyasu, T; Minoshima, T; Watanabe, K; Tanaka, H; Mochizuki, T; Taneda, K; Ota, M; Tanabe, H; Yamaguchi, H Potent inhibitors of acyl-CoA:cholesterol acyltransferase. 2. Structure-activity relationships of novel N-(2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)amides. J Med Chem 39:1262-70 (1996) [PubMed]  Article 
Target
Name:
Sterol O-acyltransferase 1
Synonyms:
ACAT-1 | Acact | Acat | Cholesterol acyltransferase 1 | SOAT1_RAT | Soat1 | Sterol O-acyltransferase, Soat
Type:
PROTEIN
Mol. Mass.:
64165.56
Organism:
Rattus norvegicus
Description:
ChEMBL_28796
Residue:
545
Sequence:
MVGEETSLRNRLSRSAENPEQDEAQKNLLDTHRNGHITMKQLIAKKRQLAAEAEELKPLFLKEVGCHFDDFVTNLIDKSASLDNGGCALTTFSILEEMKNNHRAKDLRAPPEQGKIFISRRSLLDELFEVDHIRTIYHMFIALLIIFILSTLVVDYIDEGRLVLEFSLLAYAFGQFPIVIWTWWAMFLSTLAIPYFLFQRWAHGYSKSSHPLIYSLIHGAFFLVFQLGILGFIPTYVVLAYTLPPASRFILILEQIRLVMKAHSYVRENVPRVLSAAKEKSSTVPVPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFLQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCVFNSILPGVLMLFLSFFAFLHCWLNAFAEMLRFGDRMFYKDWWNSTSYSNYYRTWNVVVHDWLYYYVYKDLLWFFSKRFRPAAMLAVFALSAVVHEYALAVCLSYFYPVLFVLFMFFGMAFNFIVNDSRKRPVWNIMVRASLFLGHGVILCFYSQEWYARQRCPLKNPTFLDYVRPRTWTCRYVF
  
Inhibitor
Name:
BDBM50050362
Synonyms:
2,2-Dimethyl-dodecanoic acid (7-methoxy-4-oxo-chroman-8-yl)-amide | CHEMBL278856
Type:
Small organic molecule
Emp. Form.:
C24H37NO4
Mol. Mass.:
403.5549
SMILES:
CCCCCCCCCCC(C)(C)C(=O)Nc1c(OC)ccc2C(=O)CCOc12
Structure:
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