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Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50051460
Substrate
n/a
Meas. Tech.
ChEMBL_28666 (CHEMBL649064)
IC50
8±n/a nM
Citation
 O'Brien, PM; Sliskovic, DR; Picard, JA; Lee, HT; Purchase, CF; Roth, BD; White, AD; Anderson, M; Mueller, SB; Bocan, T; Bousley, R; Hamelehle, KL; Homan, R; Lee, P; Krause, BR; Reindel, JF; Stanfield, RL; Turluck, D Inhibitors of acyl-CoA:cholesterol O-acyltransferase. synthesis and pharmacological activity of (+/-)-2-dodecyl-alpha-phenyl-N-(2,4,6-trimethoxyphenyl)-2H-tetrazole-5- acetamide and structurally related tetrazole amide derivatives. J Med Chem 39:2354-66 (1996) [PubMed]  Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50051460
Synonyms:
2-(2-Dodecyl-2H-tetrazol-5-yl)-2-phenyl-N-(2,4,6-trimethoxy-phenyl)-acetamide | CHEMBL77370
Type:
Small organic molecule
Emp. Form.:
C30H43N5O4
Mol. Mass.:
537.6935
SMILES:
CCCCCCCCCCCCn1nnc(n1)C(C(=O)Nc1c(OC)cc(OC)cc1OC)c1ccccc1
Structure:
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