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Target
Low-density lipoprotein receptor
Ligand
BDBM50052688
Substrate
n/a
Meas. Tech.
ChEMBL_99545 (CHEMBL707778)
EC50
2000±n/a nM
Citation
 Ashton, MJ; Brown, TJ; Fenton, G; Halley, F; Harper, MF; Lockey, PM; Porter, B; Roach, AG; Stuttle, KA; Vicker, N; Walsh, RJ New low-density lipoprotein receptor upregulators acting via a novel mechanism. J Med Chem 39:3343-56 (1996) [PubMed]  Article 
Target
Name:
Low-density lipoprotein receptor
Synonyms:
LDL receptor | LDLR | LDLR_HUMAN | Low-density lipoprotein receptor
Type:
PROTEIN
Mol. Mass.:
95343.42
Organism:
Homo sapiens (Human)
Description:
ChEMBL_99545
Residue:
860
Sequence:
MGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSRQMVSLEDDVA
  
Inhibitor
Name:
BDBM50052688
Synonyms:
CHEMBL419042 | N-[5-(3-Cyclohexyl-propionylamino)-2-methyl-phenyl]-3-hydroxy-benzamide
Type:
Small organic molecule
Emp. Form.:
C23H28N2O3
Mol. Mass.:
380.48
SMILES:
Cc1ccc(NC(=O)CCC2CCCCC2)cc1NC(=O)c1cccc(O)c1
Structure:
Search PDB for entries with ligand similarity: