Reaction Details Report a problem with these data
Target
Cathepsin B
Ligand
BDBM50053863
Substrate
n/a
Meas. Tech.
ChEMBL_47427 (CHEMBL662614)
Ki
1200±n/a nM
Citation
Li, Z; Ortega-Vilain, AC; Patil, GS; Chu, DL; Foreman, JE; Eveleth, DD; Powers, JC Novel peptidyl alpha-keto amide inhibitors of calpains and other cysteine proteases. J Med Chem 39:4089-98 (1996) [PubMed] Article
More Info.:
Target
Name:
Cathepsin B
Synonyms:
APP secretase | APPS | CATB_HUMAN | CPSB | CTSB | Cathepsin B heavy chain | Cathepsin B light chain | Cathepsin B1
Type:
Enzyme
Mol. Mass.:
37819.69
Organism:
Homo sapiens (Human)
Description:
gi_63102437
Residue:
339
Sequence:
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
Inhibitor
Name:
BDBM50053863
Synonyms:
(3-Methyl-1-{1-[2-(1-methyl-1H-pyrrol-2-yl)-ethylaminooxalyl]-propylcarbamoyl}-butyl)-carbamic acid benzyl ester | CHEMBL132773
Type:
Small organic molecule
Emp. Form.:
C26H36N4O5
Mol. Mass.:
484.5878
SMILES:
CCC(NC(=O)C(CC(C)C)NC(=O)OCc1ccccc1)C(=O)C(=O)NCCc1cccn1C