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Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50054276
Substrate
n/a
Meas. Tech.
ChEMBL_28664 (CHEMBL649062)
IC50
390±n/a nM
Citation
 White, AD; Creswell, MW; Chucholowski, AW; Blankley, CJ; Wilson, MW; Bousley, RF; Essenburg, AD; Hamelehle, KL; Krause, BR; Stanfield, RL; Dominick, MA; Neub, M Heterocyclic ureas: inhibitors of acyl-CoA:cholesterol O-acyltransferase as hypocholesterolemic agents. J Med Chem 39:4382-95 (1996) [PubMed]  Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50054276
Synonyms:
1-(2,6-Diisopropyl-phenyl)-3-(5-tridecylsulfanyl-4H-[1,2,4]triazol-3-yl)-urea | CHEMBL422452
Type:
Small organic molecule
Emp. Form.:
C28H47N5OS
Mol. Mass.:
501.771
SMILES:
CCCCCCCCCCCCCSc1nnc(NC(=O)Nc2c(cccc2C(C)C)C(C)C)[nH]1
Structure:
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