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Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50054303
Substrate
n/a
Meas. Tech.
ChEMBL_28664 (CHEMBL649062)
IC50
92±n/a nM
Citation
 White, AD; Creswell, MW; Chucholowski, AW; Blankley, CJ; Wilson, MW; Bousley, RF; Essenburg, AD; Hamelehle, KL; Krause, BR; Stanfield, RL; Dominick, MA; Neub, M Heterocyclic ureas: inhibitors of acyl-CoA:cholesterol O-acyltransferase as hypocholesterolemic agents. J Med Chem 39:4382-95 (1996) [PubMed]  Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50054303
Synonyms:
1-(2-Butyl-2,3-dihydro-1H-tetrazol-5-yl)-3-(2,6-diisopropyl-phenyl)-urea | CHEMBL442409
Type:
Small organic molecule
Emp. Form.:
C18H30N6O
Mol. Mass.:
346.4704
SMILES:
CCCCN1NN=C(NC(=O)Nc2c(cccc2C(C)C)C(C)C)N1 |t:6|
Structure:
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