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Target
Acyl-CoA:cholesterol acyltransferase
Ligand
BDBM50054307
Substrate
n/a
Meas. Tech.
ChEMBL_28664 (CHEMBL649062)
IC50
250±n/a nM
Citation
 White, AD; Creswell, MW; Chucholowski, AW; Blankley, CJ; Wilson, MW; Bousley, RF; Essenburg, AD; Hamelehle, KL; Krause, BR; Stanfield, RL; Dominick, MA; Neub, M Heterocyclic ureas: inhibitors of acyl-CoA:cholesterol O-acyltransferase as hypocholesterolemic agents. J Med Chem 39:4382-95 (1996) [PubMed]  Article 
Target
Name:
Acyl-CoA:cholesterol acyltransferase
Synonyms:
ACAT
Type:
n/a
Mol. Mass.:
35405.31
Organism:
Oryctolagus cuniculus
Description:
n/a
Residue:
305
Sequence:
PLFLKEVGSHFDDFVTNLIEKSASLDNGGCALTTFSILKEMKNNHRAKDLRAPPEQGKIFVARRSLLDELFEVDHIRTIYHMFIALLILFILSTLVVDYIDEGRLVLEFNLLSYAFGKLPTVVWTWWTMFLSTLSIPYFLFQHWANGYSKSSHPLMYSLFHGLLFMVFQLGILGFGPTYIVLAYTLPPASRFIVILEQIRLIMKAHSFVRENVPRVLNSAKEKSSTVPIPTVNQYLYFLFAPTLIYRDSYPRTPTVRWGYVAMQFAQVFGCLFYVYYIFERLCAPLFRNIKQEPFSARVLVLCIF
  
Inhibitor
Name:
BDBM50054307
Synonyms:
1-(2,6-Diisopropyl-phenyl)-3-(2-dodecyl-2H-[1,2,4]triazol-3-yl)-urea | CHEMBL136306
Type:
Small organic molecule
Emp. Form.:
C27H45N5O
Mol. Mass.:
455.6791
SMILES:
CCCCCCCCCCCCn1ncnc1NC(=O)Nc1c(cccc1C(C)C)C(C)C
Structure:
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