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Target
Type-1 angiotensin II receptor
Ligand
BDBM50503875
Substrate
n/a
Meas. Tech.
ChEMBL_1812409 (CHEMBL4311869)
Ki
1.3±n/a nM
Citation
 McKinnell, RM; Fatheree, P; Choi, SK; Gendron, R; Jendza, K; Olson Blair, B; Budman, J; Hill, CM; Hegde, LG; Yu, C; McConn, D; Hegde, SS; Marquess, DG; Klein, U Discovery of TD-0212, an Orally Active Dual Pharmacology AT ACS Med Chem Lett 10:86-91 (2019) [PubMed]  Article 
Target
Name:
Type-1 angiotensin II receptor
Synonyms:
AGTR1 | AGTR1A | AGTR1B | AGTR1_HUMAN | AT1 | AT1AR | AT1BR | AT2R1 | AT2R1B | Angiotensin II AT1 | Angiotensin II receptor | Angiotensin II type 1b (AT-1b) receptor | Type-1 angiotensin II receptor (AT1)
Type:
Protein
Mol. Mass.:
41080.75
Organism:
Homo sapiens (Human)
Description:
P30556
Residue:
359
Sequence:
MILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVIVIYFYMKLKTVASVFLLNLALADLCFLLTLPLWAVYTAMEYRWPFGNYLCKIASASVSFNLYASVFLLTCLSIDRYLAIVHPMKSRLRRTMLVAKVTCIIIWLLAGLASLPAIIHRNVFFIENTNITVCAFHYESQNSTLPIGLGLTKNILGFLFPFLIILTSYTLIWKALKKAYEIQKNKPRNDDIFKIIMAIVLFFFFSWIPHQIFTFLDVLIQLGIIRDCRIADIVDTAMPITICIAYFNNCLNPLFYGFLGKKFKRYFLQLLKYIPPKAKSHSNLSTKMSTLSYRPSDNVSSSTKKPAPCFEVE
  
Inhibitor
Name:
BDBM50503875
Synonyms:
CHEMBL4435800
Type:
Small organic molecule
Emp. Form.:
C28H34FN3O4S
Mol. Mass.:
527.651
SMILES:
CCOc1nc(CC)c(CNC(=O)[C@@H](S)CC(C)C)n1Cc1ccc(cc1F)-c1ccccc1C(O)=O |r|
Structure:
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