Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50054708
Substrate
n/a
Meas. Tech.
ChEMBL_1061 (CHEMBL616386)
IC50
5.8±n/a nM
Citation
 Norman, MH; Navas, F; Thompson, JB; Rigdon, GC Synthesis and evaluation of heterocyclic carboxamides as potential antipsychotic agents. J Med Chem 39:4692-703 (1997) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT1A | 5-hydroxytryptamine receptor 1A | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_MOUSE | Gpcr18 | Htr1a | Serotonin 1a (5-HT1a) receptor
Type:
Enzyme
Mol. Mass.:
46192.09
Organism:
Mus musculus (Mouse)
Description:
Q64264
Residue:
421
Sequence:
MDMFSLGQGNNTTTSLEPFGTGGNDTGLSNVTFSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSNPNECTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKKGAGTSFGTSSAPPPKKSLNGQPGSGDCRRSAENRAVGTPCANGAVRQGEDDATLEVIEVHRVGNSKGHLPLPSESGATSYVPACLERKNERTAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPELLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCR
  
Inhibitor
Name:
BDBM50054708
Synonyms:
1H-Indole-3-carboxylic acid [4-(4-benzo[d]isothiazol-3-yl-piperazin-1-yl)-butyl]-amide | CHEMBL142456
Type:
Small organic molecule
Emp. Form.:
C24H27N5OS
Mol. Mass.:
433.569
SMILES:
O=C(NCCCCN1CCN(CC1)c1nsc2ccccc12)c1c[nH]c2ccccc12
Structure:
Search PDB for entries with ligand similarity: