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Target
Monoglyceride lipase
Ligand
BDBM50505194
Substrate
n/a
Meas. Tech.
ChEMBL_1821757 (CHEMBL4321417)
IC50
20±n/a nM
Citation
 Otrubova, K; Chatterjee, S; Ghimire, S; Cravatt, BF; Boger, DL N-Acyl pyrazoles: Effective and tunable inhibitors of serine hydrolases. Bioorg Med Chem 27:1693-1703 (2019) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
MAG lipase | MGLL_MOUSE | Mgll | Monoacylglycerol lipase | Monoglyceride Lipase (MGL)
Type:
Hydrolase
Mol. Mass.:
33391.67
Organism:
Mus musculus (mouse)
Description:
Assays were using membranes of recombinant MAG Lipase transiently transfected in COS-7 cells.
Residue:
303
Sequence:
MPEASSPRRTPQNVPYQDLPHLVNADGQYLFCRYWKPSGTPKALIFVSHGAGEHCGRYDELAHMLKGLDMLVFAHDHVGHGQSEGERMVVSDFQVFVRDVLQHVDTIQKDYPDVPIFLLGHSMGGAISILVAAERPTYFSGMVLISPLVLANPESASTLKVLAAKLLNFVLPNMTLGRIDSSVLSRNKSEVDLYNSDPLVCRAGLKVCFGIQLLNAVARVERAMPRLTLPFLLLQGSADRLCDSKGAYLLMESSRSQDKTLKMYEGAYHVLHRELPEVTNSVLHEVNSWVSHRIAAAGAGCPP
  
Inhibitor
Name:
BDBM50505194
Synonyms:
CHEMBL4437989
Type:
Small organic molecule
Emp. Form.:
C36H33N5O3
Mol. Mass.:
583.6789
SMILES:
O=C(N1CCN(CC1)C(c1ccc(OCc2ccccc2)cc1)c1ccc(OCc2ccccc2)cc1)n1cc(cn1)C#N
Structure:
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