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Target
72 kDa type IV collagenase
Ligand
BDBM50057053
Substrate
n/a
Meas. Tech.
ChEMBL_104543 (CHEMBL718930)
Ki
94±n/a nM
Citation
 Esser, CK; Bugianesi, RL; Caldwell, CG; Chapman, KT; Durette, PL; Girotra, NN; Kopka, IE; Lanza, TJ; Levorse, DA; MacCoss, M; Owens, KA; Ponpipom, MM; Simeone, JP; Harrison, RK; Niedzwiecki, L; Becker, JW; Marcy, AI; Axel, MG; Christen, AJ; McDonnell, J; Moore, VL; Olszewski, JM; Saphos, C; Visco, DM; Hagmann, WK Inhibition of stromelysin-1 (MMP-3) by P1'-biphenylylethyl carboxyalkyl dipeptides. J Med Chem 40:1026-40 (1997) [PubMed]  Article 
Target
Name:
72 kDa type IV collagenase
Synonyms:
72 kDa gelatinase | 72 kDa type IV collagenase precursor | CLG4A | Gelatinase A | Gelatinase A (MMP-2) | MMP2 | MMP2_HUMAN | Matrix metalloproteinase-2 | Matrix metalloproteinase-2 (MMP 2) | Matrix metalloproteinase-2 (MMP2) | Matrix metalloproteinases 2 (MMP-2) | TBE-1
Type:
Enzyme
Mol. Mass.:
73870.36
Organism:
Homo sapiens (Human)
Description:
P08253
Residue:
660
Sequence:
MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC
  
Inhibitor
Name:
BDBM50057053
Synonyms:
(2S,4R)-2-Butyl-4-((S)-2,2-dimethyl-1-methylcarbamoyl-propylcarbamoyl)-6-[4'-(1H-imidazol-2-yl)-biphenyl-4-yl]-hexanoic acid | CHEMBL267722
Type:
Small organic molecule
Emp. Form.:
C33H44N4O4
Mol. Mass.:
560.7269
SMILES:
CCCC[C@@H](C[C@@H](CCc1ccc(cc1)-c1ccc(cc1)-c1ncc[nH]1)C(=O)N[C@H](C(=O)NC)C(C)(C)C)C(O)=O
Structure:
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