Reaction Details Report a problem with these data
Target
Chymase
Ligand
BDBM50059012
Substrate
n/a
Meas. Tech.
ChEMBL_49438 (CHEMBL885061)
IC50
380±n/a nM
Citation
 Niwata, S; Fukami, H; Sumida, M; Ito, A; Kakutani, S; Saitoh, M; Suzuki, K; Imoto, M; Shibata, H; Imajo, S; Kiso, Y; Tanaka, T; Nakazato, H; Ishihara, T; Takai, S; Yamamoto, D; Shiota, N; Miyazaki, M; Okunishi, H; Kinoshita, A; Urata, H; Arakawa, K Substituted 3-(phenylsulfonyl)-1-phenylimidazolidine-2,4-dione derivatives as novel nonpeptide inhibitors of human heart chymase. J Med Chem 40:2156-63 (1997) [PubMed]  Article 
Target
Name:
Chymase
Synonyms:
Alpha-chymase | CMA1 | CMA1_HUMAN | CYH | CYM | Chymase precursor | Mast cell protease I
Type:
Enzyme
Mol. Mass.:
27340.12
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
247
Sequence:
MLLLPLPLLLFLLCSRAEAGEIIGGTECKPHSRPYMAYLEIVTSNGPSKFCGGFLIRRNFVLTAAHCAGRSITVTLGAHNITEEEDTWQKLEVIKQFRHPKYNTSTLHHDIMLLKLKEKASLTLAVGTLPFPSQFNFVPPGRMCRVAGWGRTGVLKPGSDTLQEVKLRLMDPQACSHFRDFDHNLQLCVGNPRKTKSAFKGDSGGPLLCAGVAQGIVSYGRSDAKPPAVFTRISHYRPWINQILQAN
  
Inhibitor
Name:
BDBM50059012
Synonyms:
3-(4-Chloro-benzenesulfonyl)-1-phenyl-imidazolidine-2,4-dione | CHEMBL69991
Type:
Small organic molecule
Emp. Form.:
C15H11ClN2O4S
Mol. Mass.:
350.777
SMILES:
Clc1ccc(cc1)S(=O)(=O)N1C(=O)CN(C1=O)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: