Reaction Details Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM50059405
Substrate
n/a
Meas. Tech.
ChEMBL_29470 (CHEMBL642199)
Ki
8200.0±n/a nM
Citation
 Jiang, J; van Rhee, AM; Chang, L; Patchornik, A; Ji, XD; Evans, P; Melman, N; Jacobson, KA Structure-activity relationships of 4-(phenylethynyl)-6-phenyl-1,4-dihydropyridines as highly selective A3 adenosine receptor antagonists. J Med Chem 40:2596-608 (1997) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
AA1R_RAT | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | Adenosine A1 receptor (A1) | Adenosine receptor | Adenosine receptors A1 | Adora1
Type:
Protein
Mol. Mass.:
36704.13
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
326
Sequence:
MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSVVEQDWRANGSVGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFLKIWNDHFRCQPKPPIDEDLPEEKAED
  
Inhibitor
Name:
BDBM50059405
Synonyms:
2-Methyl-6-phenyl-4-phenylethynyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester | CHEMBL328932
Type:
Small organic molecule
Emp. Form.:
C24H21NO4
Mol. Mass.:
387.4278
SMILES:
CCOC(=O)C1C(C#Cc2ccccc2)C(C(O)=O)=C(N=C1C)c1ccccc1 |c:19,21|
Structure:
Search PDB for entries with ligand similarity: