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Target
Falcipain 2
Ligand
BDBM50059580
Substrate
n/a
Meas. Tech.
ChEMBL_69691 (CHEMBL682027)
IC50
30000±n/a nM
Citation
 Domínguez, JN; López, S; Charris, J; Iarruso, L; Lobo, G; Semenov, A; Olson, JE; Rosenthal, PJ Synthesis and antimalarial effects of phenothiazine inhibitors of a Plasmodium falciparum cysteine protease. J Med Chem 40:2726-32 (1997) [PubMed]  Article 
Target
Name:
Falcipain 2
Synonyms:
Cysteine protease falcipain-2 | Falcipain 2 | Falcipain-2
Type:
Enzyme
Mol. Mass.:
55912.60
Organism:
Plasmodium falciparum
Description:
Recombinant falcipain-2.
Residue:
484
Sequence:
MDYNMDYAPHEVISQQGERFVDKYVDRKILKNKKSLLVIISLSVLSVVGFVLFYFTPNSRKSDLFKNSSVENNNDDYIINSLLKSPNGKKFIVSKIDEALSFYDSKKNDINKYNEGNNNNNADFKGLSLFKENTPSNNFIHNKDYFINFFDNKFLMNNAEHINQFYMFIKTNNKQYNSPNEMKERFQVFLQNAHKVNMHNNNKNSLYKKELNRFADLTYHEFKNKYLSLRSSKPLKNSKYLLDQMNYEEVIKKYRGEENFDHAAYDWRLHSGVTPVKDQKNCGSCWAFSSIGSVESQYAIRKNKLITLSEQELVDCSFKNYGCNGGLINNAFEDMIELGGICPDGDYPYVSDAPNLCNIDRCTEKYGIKNYLSVPDNKLKEALRFLGPISISVAVSDDFAFYKEGIFDGECGDQLNHAVMLVGFGMKEIVNPLTKKGEKHYYYIIKNSWGQQWGERGFINIETDESGLMRKCGLGTDAFIPLIE
  
Inhibitor
Name:
BDBM50059580
Synonyms:
7-Chloro-2,2-dimethyl-2,3-dihydro-1H,10H-phenothiazin-4-one | CHEMBL92872
Type:
Small organic molecule
Emp. Form.:
C14H14ClNOS
Mol. Mass.:
279.785
SMILES:
CC1(C)CC(=O)C2Sc3cc(Cl)ccc3N=C2C1 |c:16|
Structure:
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