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Target
Growth factor receptor-bound protein 2
Ligand
BDBM50060520
Substrate
n/a
Meas. Tech.
ChEMBL_63776 (CHEMBL677218)
IC50
7900±n/a nM
Citation
 Furet, P; Gay, B; García-Echeverría, C; Rahuel, J; Fretz, H; Schoepfer, J; Caravatti, G Discovery of 3-aminobenzyloxycarbonyl as an N-terminal group conferring high affinity to the minimal phosphopeptide sequence recognized by the Grb2-SH2 domain. J Med Chem 40:3551-6 (1997) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50060520
Synonyms:
(S)-4-Amino-4-[(S)-1-[(1S,2S)-1-((S)-1,2-dicarbamoyl-ethylcarbamoyl)-2-methyl-butylcarbamoyl]-2-(4-phosphonooxy-phenyl)-ethylcarbamoyl]-butyric acid | CHEMBL332374
Type:
Small organic molecule
Emp. Form.:
C24H37N6O11P
Mol. Mass.:
616.5579
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(=O)[C@@H](N)CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(N)=O
Structure:
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