Reaction Details Report a problem with these data
Target
Neuropeptide Y receptor type 1
Ligand
BDBM50060730
Substrate
n/a
Meas. Tech.
ChEMBL_143827 (CHEMBL748712)
Ki
98±n/a nM
Citation
 Hipskind, PA; Lobb, KL; Nixon, JA; Britton, TC; Bruns, RF; Catlow, J; Dieckman-McGinty, DK; Gackenheimer, SL; Gitter, BD; Iyengar, S; Schober, DA; Simmons, RM; Swanson, S; Zarrinmayeh, H; Zimmerman, DM; Gehlert, DR Potent and selective 1,2,3-trisubstituted indole NPY Y-1 antagonists. J Med Chem 40:3712-4 (1997) [PubMed]  Article 
Target
Name:
Neuropeptide Y receptor type 1
Synonyms:
NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44399.07
Organism:
Homo sapiens (Human)
Description:
NPY-Y1 NPY1R HUMAN::P25929
Residue:
384
Sequence:
MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
  
Inhibitor
Name:
BDBM50060730
Synonyms:
1'-[2-(4-Chloro-phenoxymethyl)-1-(2-piperidin-1-yl-ethyl)-1H-indol-3-ylmethyl]-[1,4']bipiperidinyl | CHEMBL121636
Type:
Small organic molecule
Emp. Form.:
C33H45ClN4O
Mol. Mass.:
549.19
SMILES:
Clc1ccc(OCc2c(CN3CCC(CC3)N3CCCCC3)c3ccccc3n2CCN2CCCCC2)cc1
Structure:
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